Novel model of multiple sclerosis induced by EBV-like virus generates a unique B cell population.
J Neuroimmunol
; 394: 578408, 2024 09 15.
Article
en En
| MEDLINE
| ID: mdl-39098102
ABSTRACT
Epstein-Barr virus (EBV) is deemed a necessary, yet insufficient factor in the development of multiple sclerosis (MS). In this study, myelin basic protein-specific transgenic T cell receptor mice were infected with murid gammaherpesvirus 68 virus (MHV68), an EBV-like virus that infects mice, resulting in the onset neurological deficits at a significantly higher frequency than influenza or mock-infected mice. MHV68 infected mice exhibited signs including optic neuritis and ataxia which are frequently observed in MS patients but not in experimental autoimmune encephalomyelitis mice. MHV68-infected mice exhibited increased focal immune cell infiltration in the central nervous system. Single cell RNA sequencing identified the emergence of a population of B cells that express genes associated with antigen presentation and costimulation, indicating that gammaherpesvirus infection drives a distinct, pro-inflammatory transcriptional program in B cells that may promote autoreactive T cell responses in MS.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratones Transgénicos
/
Linfocitos B
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Modelos Animales de Enfermedad
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Esclerosis Múltiple
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2024
Tipo del documento:
Article