Emerging Adjuvant Thrombolytic Therapies for Acute Ischemic Stroke Reperfusion.

Yogendrakumar, Vignan; Vandelanotte, Sarah; Mistry, Eva A; Hill, Michael D; Coutts, Shelagh B; Nogueira, Raul G; Nguyen, Thanh N; Medcalf, Robert L; Broderick, Joseph P; De Meyer, Simon F; Campbell, Bruce C V

Yogendrakumar, Vignan; Vandelanotte, Sarah; Mistry, Eva A; Hill, Michael D; Coutts, Shelagh B; Nogueira, Raul G; Nguyen, Thanh N; Medcalf, Robert L; Broderick, Joseph P; De Meyer, Simon F; Campbell, Bruce C V.

Afiliación

Yogendrakumar V; Division of Neurology, The Ottawa Hospital and Ottawa Hospital Research Institute, University of Ottawa, Canada (V.Y.).
Vandelanotte S; Department of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Australia (V.Y., B.C.V.C.).
Mistry EA; Laboratory for Thrombosis Research, KU Leuven Campus Kulak, Kortrijk, Belgium (S.V., S.F.D.M.).
Hill MD; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (E.A.M., J.P.B.).
Coutts SB; Department of Clinical Neurosciences, Radiology, and Community Health Sciences, Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Canada (M.D.H., S.B.C.).
Nogueira RG; Department of Clinical Neurosciences, Radiology, and Community Health Sciences, Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Canada (M.D.H., S.B.C.).
Nguyen TN; Department of Neurology, University of Pittsburgh, PA (R.G.N.).
Medcalf RL; Department of Neurology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, MA (T.N.N.).
Broderick JP; Central Clinical School, Australian Centre for Blood Diseases, Monash University, Australia (R.L.M.).
De Meyer SF; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (E.A.M., J.P.B.).
Campbell BCV; Gardner Neuroscience Institute, Cincinnati, OH (J.P.B.).

Stroke ; 55(10): 2536-2546, 2024 Oct.

Article en En | MEDLINE | ID: mdl-39105286

ABSTRACT

ABSTRACT

Thrombolytic therapies for acute ischemic stroke are widely available but only result in recanalization early enough, to be therapeutically useful, in 10% to 30% of cases. This large gap in treatment effectiveness could be filled by novel therapies that can increase the effectiveness of thrombus clearance without significantly increasing the risk of harm. This focused update will describe the current state of emerging adjuvant treatments for acute ischemic stroke reperfusion. We focus on new treatments that are designed to (1) target different components that make up a stroke thrombus, (2) enhance endogenous fibrinolytic systems, (3) reduce stagnant blood flow, and (4) improve recanalization of distal thrombi and postendovascular thrombectomy.

Palabras clave

reperfusion; stroke; thrombectomy; thrombolytic therapy; treatment outcome

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Stroke Año: 2024 Tipo del documento: Article