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Electroacupuncture improves cognitive impairment after ischemic stroke based on regulation of mitochondrial dynamics through SIRT1/PGC-1α pathway.
Chen, Limin; Chen, Shuying; Bai, Yanjie; Zhang, Yongchuang; Li, Xiaoxiao; Wang, Yan; Xiao, Yuqian; Wan, Jun; Sun, Kexin.
Afiliación
  • Chen L; Rehabilitation Medicine School of Henan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, People's Hospital of Henan University of Chinese Medicine, Department of Rehabilitation Medicine of Zhengzhou People's Hospital (South Hospital), Zhengzhou,
  • Chen S; Rehabilitation Medicine School of Henan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Bai Y; Rehabilitation Centre of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China. Electronic address: baiyj66@126.com.
  • Zhang Y; Rehabilitation Medicine School of Henan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Li X; Rehabilitation Medicine School of Henan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Wang Y; Rehabilitation Centre of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Xiao Y; Rehabilitation Medicine School of Henan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Wan J; Rehabilitation Medicine School of Henan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
  • Sun K; Rehabilitation Medicine School of Henan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Brain Res ; 1844: 149139, 2024 Dec 01.
Article en En | MEDLINE | ID: mdl-39111521
ABSTRACT
In recent years, the mechanism of acupuncture in the treatment of post-stroke cognitive impairment (PSCI) has not been fully elucidated. The balance between mitochondrial fission and fusion is important for PSCI. Our previous research demonstrated that electroacupuncture can improve learning and memory in middle cerebral artery ischemia reperfusion (MCAO/R) rats. However, the specific mechanism by which electroacupuncture improves learning and memory in MCAO/R rats by regulating mitochondrial fission and fusion needs to be further investigated. The MCAO/R rats was developed using the line-bolt method. The rats were randomly divided into sham-operated (Sham), model (MCAO/R), electroacupuncture (MCAO/R + EA) and sham-electroacupuncture (MCAO/R + sham EA) groups. Investigating the effects of EA on the expression of Sirtuin1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), Optic atrophy 1R + (OPA1) and Dynamin-related protein 1 (DRP1) in hippocampal neurons and on the morphology and function of hippocampal neurons and mitochondria. EA was able to reduce neurologic deficit scores and cerebral infarct volume and improve new object discrimination in MCAO/R rats, but there were no significant changes in these indices in the sham-electroacupuncture group. Moreover, EA increased the expression of SIRT1, PGC-1α, and OPA1 in hippocampal tissues, inhibited the expression of DRP1, attenuated neuronal and mitochondrial damage, and reduced mitochondrial fragmentation. The mechanism by which EA improves learning memory deficits in MCAO/R rats may be related to the inhibition of SIRT1/PGC-1α expression, the enhancement of mitochondrial fusion and the obstruction of its fission, and the reduction of hippocampal neuronal damage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Infarto de la Arteria Cerebral Media / Disfunción Cognitiva / Dinámicas Mitocondriales / Accidente Cerebrovascular Isquémico / Hipocampo Límite: Animals Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Infarto de la Arteria Cerebral Media / Disfunción Cognitiva / Dinámicas Mitocondriales / Accidente Cerebrovascular Isquémico / Hipocampo Límite: Animals Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article
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