[Can muscle invasive bladder cancer be treated without cystectomy in the future? : New data on trimodal therapy and bladder preservation after systemic therapy alone]. / Kann beim muskelinvasiven Urothelkarzinom der Harnblase zukünftig auf die Zystektomie verzichtet werden? : Neue Daten zur trimodalen Therapie und zum Blasenerhalt nach reiner Systemtherapie.
Urologie
; 63(10): 985-993, 2024 Oct.
Article
en De
| MEDLINE
| ID: mdl-39143395
ABSTRACT
Muscle invasive bladder cancer is generally an aggressive disease. Radical cystectomy (RC) is traditionally the treatment of choice. Due to possible advantages in morbidity, peri-interventional mortality, and quality of life, bladder-preserving treatment strategies are of interest. Here, trimodal therapy (TMT) consisting of maximum transurethral resection and subsequent radiochemotherapy with subsequent cystoscopic follow-up plays an important role. Current cohort analyses indicate equivalent oncological results of TMT to RC in selected patients. However, the use of systemic therapy alone with combined chemo-/immunotherapy or cytotoxic combination therapy also shows promising efficacy both in early surrogate parameters and in oncological endpoints. Overall, studies to date suggest that bladder preservation is possible without compromising oncologic outcomes. Future developments aim to refine patient selection by combining different risk factors and biomarkers to further improve outcomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
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Cistectomía
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Tratamientos Conservadores del Órgano
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Invasividad Neoplásica
Límite:
Humans
Idioma:
De
Revista:
Urologie
Año:
2024
Tipo del documento:
Article