Rationally reprogramming single-cell aging trajectories and lifespan through dynamic modulation of environmental inputs.

Smart, Matthew; Moreno, David F; Acar, Murat

Smart, Matthew; Moreno, David F; Acar, Murat.

Afiliación

Smart M; Center for Computational Biology, Flatiron Institute, New York, NY, USA.
Moreno DF; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Acar M; Department of Basic Medical Sciences, School of Medicine, Koç University, Sariyer, Istanbul, Türkiye; Koç University Research Center for Translational Medicine, Sariyer, Istanbul, Türkiye. Electronic address: macar@ku.edu.tr.

Cell Syst ; 15(8): 676-678, 2024 Aug 21.

Article en En | MEDLINE | ID: mdl-39173583

ABSTRACT

ABSTRACT

How do variations in nutrient levels influence cellular lifespan? A dynamical systems model of a core circuit involved in yeast aging suggests principles underlying lifespan extension observed at static and alternating glucose levels that are reminiscent of intermittent fasting regimens.

Asunto(s)

Senescencia Celular; Saccharomyces cerevisiae; Saccharomyces cerevisiae/fisiología; Saccharomyces cerevisiae/genética; Senescencia Celular/fisiología; Glucosa/metabolismo; Modelos Biológicos; Análisis de la Célula Individual/métodos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Senescencia Celular Idioma: En Revista: Cell Syst Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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