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Opposing GPCR signaling programs protein intake setpoint in Drosophila.
Wu, Guangyan; Ma, Tianji; Hancock, Clare E; Gonzalez, Santiago; Aryal, Binod; Vaz, Sharon; Chan, Gabrielle; Palarca-Wong, Madison; Allen, Nick; Chung, Chan-I; Shu, Xiaokun; Liu, Qili.
Afiliación
  • Wu G; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Ma T; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Hancock CE; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Gonzalez S; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Aryal B; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Vaz S; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Chan G; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Palarca-Wong M; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Allen N; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Chung CI; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Shu X; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Liu Q; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: qili.liu@ucsf.edu.
Cell ; 187(19): 5376-5392.e17, 2024 Sep 19.
Article en En | MEDLINE | ID: mdl-39197448
ABSTRACT
Animals defend a target level for their fundamental needs, including food, water, and sleep. Deviation from the target range, or "setpoint," triggers motivated behaviors to eliminate that difference. Whether and how the setpoint itself is encoded remains enigmatic for all motivated behaviors. Employing a high-throughput feeding assay in Drosophila, we demonstrate that the protein intake setpoint is set to different values in male, virgin female, and mated female flies to meet their varying protein demands. Leveraging this setpoint variability, we found, remarkably, that the information on the intake setpoint is stored within the protein hunger neurons as the resting membrane potential. Two RFamide G protein-coupled receptor (GPCR) pathways, by tuning the resting membrane potential in opposite directions, coordinately program and adjust the protein intake setpoint. Together, our studies map the protein intake setpoint to a single trackable physiological parameter and elucidate the cellular and molecular mechanisms underlying setpoint determination and modulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas de Drosophila / Receptores Acoplados a Proteínas G / Drosophila melanogaster / Neuronas Límite: Animals Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas de Drosophila / Receptores Acoplados a Proteínas G / Drosophila melanogaster / Neuronas Límite: Animals Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos