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Comparison of ultrasound findings of papillary thyroid carcinoma subtypes based on the 2022 WHO classification of thyroid neoplasms.
Hekimsoy, Ilhan; Ertan, Yesim; Serin, Gürdeniz; Karabulut, Ahmet Kasim; Özbek, Süha Süreyya.
Afiliación
  • Hekimsoy I; Department of Radiology, Izmir Torbali State Hospital, Izmir, Türkiye.
  • Ertan Y; Department of Pathology, Ege University Faculty of Medicine, Izmir, Türkiye.
  • Serin G; Department of Pathology, Ege University Faculty of Medicine, Izmir, Türkiye.
  • Karabulut AK; Department of Radiology, Ege University Faculty of Medicine, Bornova, Türkiye.
  • Özbek SS; Department of Radiology, Ege University Faculty of Medicine, Bornova, Türkiye.
Front Endocrinol (Lausanne) ; 15: 1434787, 2024.
Article en En | MEDLINE | ID: mdl-39205684
ABSTRACT

Purpose:

The present study aimed to analyze and compare sonographic features of papillary thyroid carcinoma (PTC) subtypes to determine whether ultrasound (US) may aid in differentiating particular subtypes.

Methods:

This retrospective study enrolled 133 patients diagnosed with 142 histopathologically proven PTCs as per the fifth edition of the World Health Organization classification of thyroid neoplasms between January 2013 and May 2023. US features based on the American College of Radiology and European Thyroid Imaging and Reporting Data Systems (TIRADS), and histopathological characteristics of nodules were assessed and compared.

Results:

Histopathological analysis yielded 55 (38.7%) classic PTC, 32 (22.5%) invasive encapsulated follicular variant (IEFV) PTC, 20 (14.1%) oncocytic subtype, 14 (9.9%) non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 11 (7.8%) infiltrative follicular subtype, 7 (4.9%) tall cell subtype, 2 (1.4%) solid subtype, and 1 (0.7%) diffuse sclerosing subtype. The US findings indicating malignancy, such as taller-than-wide shape, irregular margins, echogenic foci, and higher TIRADS categories, were more frequently demonstrated in nodules with classic PTC and the tall cell subtype, in line with their histopathological features. Conversely, IEFV-PTC and NIFTP rarely exhibited these high-risk sonographic features. US appearance of the oncocytic subtype more frequently overlapped with IEFV-PTC, yet hypo/very hypoechoic nodules with larger nodular diameters and higher TIRADS scores may favor the diagnosis of this subtype.

Conclusion:

US features of certain subtypes may guide the differential diagnosis regarding shape, margin, echogenic foci, and TIRADS category of nodules; however, definitive subtyping is not yet possible using US images alone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organización Mundial de la Salud / Neoplasias de la Tiroides / Ultrasonografía / Cáncer Papilar Tiroideo Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organización Mundial de la Salud / Neoplasias de la Tiroides / Ultrasonografía / Cáncer Papilar Tiroideo Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article
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