Ameliorating effects of selenium nanoparticle coated by gallic acid on histological and biochemical parameters of testis in azoospermic rat model.
Tissue Cell
; 91: 102550, 2024 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-39236520
ABSTRACT
This study was designed to examine the effects of selenium nanoparticles (SeNPs) coated with gallic acid (GA) on testis in azoospermic rats. Thirty-six adult Wistar rats were assigned to six groups control (1â¯ml intraperitoneal (i.p.) phosphate-buffered saline (PBS) for 7 consecutive days), SHAM (single i.p. injection of 1â¯ml of 8â¯% dimethyl sulfoxide (DMSO)), BUS (single i.p. injection of busulfan (BUS) 30â¯mg/kg body weight), GA (single i.p. injection of BUS 30â¯mg/kg on day 1, 100â¯mg/kg body weight GA from days 2-7), SeNPs (single i.p. injection of BUS 30â¯mg/kg on day 1, 0.5â¯mg/kg body weight SeNPs from days 2-7), and SeNPs-GA (single i.p. injection of BUS 30â¯mg/kg on day 1, 0.5â¯mg/kg body weight SeNPs-GA from days 2-7). Subsequently, serum levels of testosterone and insulin-like growth factor-1 (IGF-1), antioxidant markers, sperm parameters, and histological parameters were evaluated. The results showed that BUS injection induced azoospermia in rats by causing oxidative stress and testicular tissue damage. In contrast, co-administration of SeNPs and GA showed significant improvements in testosterone and IGF-1 levels, antioxidant status, testicular tissue characteristics, and sperm parameters. Overall, the findings suggest that GA-coated SeNPs offer therapeutic potential in BUS-induced azoospermic models.
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01-internacional
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MEDLINE
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En
Revista:
Tissue Cell
Año:
2024
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Article