Identification of Bipolar Disorder and Schizophrenia Based on Brain CT and Deep Learning Methods.

ABSTRACT

With the increasing prevalence of mental illness, accurate clinical diagnosis of mental illness is crucial. Compared with MRI, CT has the advantages of wide application, low price, short scanning time, and high patient cooperation. This study aims to construct a deep learning (DL) model based on CT images to make identification of bipolar disorder (BD) and schizophrenia (SZ). A total of 506 patients (BD = 227, SZ = 279) and 179 healthy controls (HC) was collected from January 2022 to May 2023 at two hospitals, and divided into an internal training set and an internal validation set according to a ratio of 41. An additional 65 patients (BD = 35, SZ = 30) and 40 HC were recruited from different hospitals, and served as an external test set. All subjects accepted the conventional brain CT examination. The DenseMD model for identify BD and SZ using multiple instance learning was developed and compared with other classical DL models. The results showed that DenseMD performed excellently with an accuracy of 0.745 in the internal validation set, whereas the accuracy of the ResNet-18, ResNeXt-50, and DenseNet-121model was 0.672, 0.664, and 0.679, respectively. For the external test set, DenseMD again outperformed other models with an accuracy of 0.724; however, the accuracy of the ResNet-18, ResNeXt-50, and DenseNet-121model was 0.657, 0.638, and 0.676, respectively. Therefore, the potential of DL models for identification of BD and SZ based on brain CT images was established, and identification ability of the DenseMD model was better than other classical DL models.