Interaction of papaverine with covalently closed DNA.
Microbiologica
; 8(3): 263-8, 1985 Jul.
Article
en En
| MEDLINE
| ID: mdl-4033454
ABSTRACT
Cyclic nucleotides influence viral replication and papaverine, as an inhibitor of phosphodiesterase, also affects the replication of both DNA and RNA viruses through an increase in cAMP levels. Moreover in vitro papaverine affects neither protein synthesis nor several polymerases, while it inhibits DNA synthesis. Static fluorescence studies on the interaction of the drug with ColE1 plasmid covalently closed DNA indicate that the drug binds to the nucleic acid, probably by intercalation. A comparison between the binding characteristics of Papaverine and Actinomycin D is also reported.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papaverina
/
Plásmidos
/
ADN Circular
/
Plásmidos de Bacteriocinas
Idioma:
En
Revista:
Microbiologica
Año:
1985
Tipo del documento:
Article