Nitrosation of quaternary ammonium compounds in vivo in the Wistar rat.
Xenobiotica
; 15(12): 1061-8, 1985 Dec.
Article
en En
| MEDLINE
| ID: mdl-4090526
ABSTRACT
Animals dosed orally with nitrite (1.5 X 10(-3) mol/kg) and nonyl dimethylbenzylammonium bromide (2.9 X 10(-4) mol/kg) exhibit liver damage within two hours; cetyl trimethylammonium bromide plus nitrite was not significantly hepatotoxic. Both nonyl dimethylbenzyl ammonium bromide and cetyl trimethylammonium bromide were demethylated by rat-liver microsomal preparations; substrate concentrations of 1 mM or more were inhibitory. Bile from rats given i.p. doses of cetyl trimethylammonium bromide, nonyl dimethylbenzylammonium bromide or dodecyl dimethylbenzylammonium bromide contains only metabolites, no unchanged compounds were detected.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratas Endogámicas
/
Compuestos de Amonio Cuaternario
/
Nitritos
Límite:
Animals
Idioma:
En
Revista:
Xenobiotica
Año:
1985
Tipo del documento:
Article