Benzodiazepines and reproduction of swiss-webster mice.
Res Commun Chem Pathol Pharmacol
; 13(4): 601-10, 1976 Apr.
Article
en En
| MEDLINE
| ID: mdl-4863
ABSTRACT
Chronic dietary administration of 6 different benzodiazepine tranquilizers (chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, and nitrazepam) to breeding pairs of Swiss-Webster mice resulted in alterations of the normal patterns of reproductive behavior and fetal growth. Significant decreases in mating performance were seen among mice given diets containing 0.15% chlordiazepoxide, 0.05% diazepam, 0.05 and 0.15% oxazepam, 0.02 and 0.10% prazepam, 0.10% flurazepam, and 0.025% nitrazepam. Offspring in all drug treatments showed significantly depressed body weights at birth.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reproducción
/
Ansiolíticos
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Res Commun Chem Pathol Pharmacol
Año:
1976
Tipo del documento:
Article