Squalene epoxidase, oxido-squalene cyclase and cholesterol biosynthesis in normal and tumoral mucosa of the human gastro-intestinal tract. Evidence of post-HHG CoA regulation.
Biochim Biophys Acta
; 666(3): 433-41, 1981 Dec 23.
Article
en En
| MEDLINE
| ID: mdl-6173065
ABSTRACT
Cholesterol biosynthesis was evaluated in different parts of the human gastro-intestinal tract by incorporation of labelled acetic or mevalonic acid into non-saponifiable metabolites and also by measuring squalene epoxidase activity, oxido=squalene cyclase activity and dihydrolanosterol demethylation rate. With respect to rat liver, whole cholesterol biosynthesis was generally low and we found an anatomic localization of activity towards the end of the gastro-intestinal tract. The results of analysis of mevalonic acid metabolites implied the existence of post-HMG CoA regulation. A comparison with the corresponding dat obtained from homologous cancerous tissues (inthe case of high cholesterogenic activity) did not show a greater activity in the tumor, in spite of higher levels of epoxidase concentration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxigenasas
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Colesterol
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Transferasas Intramoleculares
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Mucosa Gástrica
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Neoplasias Gastrointestinales
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Glutaratos
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Meglutol
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Mucosa Intestinal
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Isomerasas
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Microsomas
Límite:
Adult
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Aged
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Animals
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Female
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Humans
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Middle aged
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Pregnancy
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1981
Tipo del documento:
Article