[Biological activity of a new Soviet natural inducer, double-stranded RNA]. / Biologicheskaia aktivnost' novogo otechestvennogo prirodnogo induktora--dvunitevoi RNK.
Antibiotiki
; 25(1): 28-32, 1980 Jan.
Article
en Ru
| MEDLINE
| ID: mdl-6243898
ABSTRACT
Antiviral activity of a two-spiral RNA (ts RNA), a new natural interferon inductor was studied. It was shown that ts RNA extracted from a phage infected E. coli culture was an active inductor of interferon and resistance to infection with the forestspring encephalitis virus experimental animals. In experiments on 10-12 g mice ts RNA administered in a dose of 50 micrograms/mouse 6 hours after the infection induced up to 1280 units/ml of the serum interferon. When the inductor was administered repeatedly, the experimental animals developed hyporeactivity resulting in a marked decrease in interferon production after the 3rd subsequent injection. The most pronounced effect with respect to the forest-spring encephalitis virus was observed when the inductor was administered intraperitoneally in a dose of 20 micrograms/mouse 4 hours before the infection. The protective effect was less pronounced when the inductor was administered 24 and 48 hours before the infection. A two-fold administration of the inductor did not increase the antiviral effect. When the inductor was administered in a dose of 100 micrograms 14 days before the infection, the animals showed an increase in the nonspecific resistance to the infection resulting in a marked antiviral effect.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
4_TD
Problema de salud:
4_tick_borne_encephalitis
Asunto principal:
ARN Bicatenario
/
Inductores de Interferón
Límite:
Animals
Idioma:
Ru
Revista:
Antibiotiki
Año:
1980
Tipo del documento:
Article