The effect of DMSO treatment on the performance of [99mTc]HEDP.
Int J Nucl Med Biol
; 11(2): 109-11, 1984.
Article
en En
| MEDLINE
| ID: mdl-6434460
The effect of treating a commercial skeletal imaging kit containing hydroxyethylidene diphosphonate (HEDP) with dimethyl sulfoxide (DMSO) prior to labeling with sodium pertechnetate, 99mTc[TcO4-], was investigated. Statistically, significant differences (P less than 0.05) in soft tissue retention (blood and muscle) were seen in rats after injection with the DMSO-treated HEDP compared to the nontreated HEDP. Based on i.r. and HPLC data, it appears that DMSO acts as an extractant for certain Sn2+-HEDP complexes which contribute to greater soft-tissue retention.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Huesos
/
Compuestos de Organotecnecio
/
Dimetilsulfóxido
/
Tecnecio
/
Ácido Etidrónico
/
Músculos
Límite:
Animals
Idioma:
En
Revista:
Int J Nucl Med Biol
Año:
1984
Tipo del documento:
Article