Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: I. The role of peroxidation of membrane phospholipids.
Acta Physiol Pharmacol Bulg
; 10(2): 73-81, 1984.
Article
en En
| MEDLINE
| ID: mdl-6485825
ABSTRACT
It was demonstrated that endogenous lipid peroxidation (LPO) is an effective mechanism of disassembly of endoplasmic reticulum membranes and cytochrome P-450 (P-448) in the liver. The rate of cytochrome P-450 (P-448) degradation in vivo can be regulated by free radical scavengers. The constitutive forms of cytochrome P-450 (P-448) are less sensitive to LPO induced in vivo or in vitro than the inducible ones.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retículo Endoplásmico
/
Oxigenasas de Función Mixta
/
Peróxidos Lipídicos
/
Hígado
/
Lípidos de la Membrana
Límite:
Animals
Idioma:
En
Revista:
Acta Physiol Pharmacol Bulg
Año:
1984
Tipo del documento:
Article