Studies on the duration of local anesthesia: a possible mechanism for the prolonging effect of "vasoconstrictors" on the duration of infiltration anesthesia.
Int J Oral Surg
; 9(2): 144-7, 1980 Apr.
Article
en En
| MEDLINE
| ID: mdl-6773898
ABSTRACT
Attempts have been made to correlate the duration of the local anesthetic effect with the amount of the local anesthetic compound remaining at the injection site at different times after an injection. In addition to delaying the absorption of the local anesthetic, adrenaline but not a vasopressin-derivate decreased the minimal anesthetic concentration of the local anesthetic agent. It is assumed that the pH value of the tissues at the injection site was kept down through the metabolic effects of adrenaline, thereby transforming the local anesthetic agent into cations, which is the form in which the amide-type of local anesthetics mainly exerts their nerve blocking activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ornipresina
/
Vasopresinas
/
Epinefrina
/
Anestesia Local
/
Mepivacaína
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Int J Oral Surg
Año:
1980
Tipo del documento:
Article