Naloxone attenuates self-abusive behavior in developmentally disabled clients.
Appl Res Ment Retard
; 4(1): 5-11, 1983.
Article
en En
| MEDLINE
| ID: mdl-6870234
ABSTRACT
The opiate antagonist naloxone was effective in reducing self-abusive behavior in two mentally retarded clients with an extensive history of such behavior. Three doses of naloxone (0.1, 0.2, 0.4 mg) were compared with a vehicle solution in a double-blind, crossover design. Naloxone greatly attenuated self-abusive episodes in one client and eliminated them entirely in the second client. In addition, use of self-restraining behavior by one client was reduced. The findings suggested that some clients with self-injurious behavior may have disturbances of the endogenous opiate system. Maintenance of self-abuse by tonically elevated pain threshold and/or by the putative addictive characteristics of such behavior was discussed.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
8_ODS3_consumo_sustancias_psicoactivas
Problema de salud:
8_opioid_abuse
Asunto principal:
Automutilación
/
Naloxona
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Appl Res Ment Retard
Año:
1983
Tipo del documento:
Article