First pass biotransformation of ethinylestradiol in rat small intestine in situ.
Naunyn Schmiedebergs Arch Pharmacol
; 321(3): 223-5, 1982 Dec.
Article
en En
| MEDLINE
| ID: mdl-7155203
ABSTRACT
The intestinal absorption and biotransformation of ethinylestradiol and of ethinylestradiol glucuronide in rats were studied using a jejunal loop preparation in situ. Radioactivity associated with ethinylestradiol almost completely appeared in the venous outflow within 80 min. Forty two percent was present as unchanged compound, 56% in the glucuronide fraction and 2% as sulfate ester. Absorption of ethinylestradiol glucuronide was about 20 times slower than absorption of the nonconjugated molecule. The data indicate, that intestinal absorption of ethinylestradiol involves several superimposed kinetics and that glucuronidation in the gut may result in a decreased bioavailability of the compound.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Etinilestradiol
/
Intestino Delgado
Límite:
Animals
Idioma:
En
Revista:
Naunyn Schmiedebergs Arch Pharmacol
Año:
1982
Tipo del documento:
Article