Transcriptional regulation of rat hepatic low-density lipoprotein receptor and cholesterol 7 alpha hydroxylase by thyroid hormone.
Arch Biochem Biophys
; 323(2): 404-8, 1995 Nov 10.
Article
en En
| MEDLINE
| ID: mdl-7487105
ABSTRACT
Utilizing hypophysectomized and thyroidectomized rats, it is demonstrated that the rapid increase in expression of hepatic low-density lipoprotein (LDL) receptor and cholesterol 7 alpha-hydroxylase in response to thyroid hormone is due to increases in the rates of transcription of these genes. An increase in transcription of the hepatic LDL receptor gene was seen within 30 min after administration of triiodothyronine. The increase in transcription fully accounted for the increase in hepatic LDL receptor protein. Stimulation of transcription of these two genes provides for enhanced removal of LDL from serum and elimination from the body.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triyodotironina
/
Receptores de LDL
/
Colesterol 7-alfa-Hidroxilasa
/
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Límite:
Animals
Idioma:
En
Revista:
Arch Biochem Biophys
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos