Characterization of the 5' region of the CD10/neutral endopeptidase 24.11 gene.
Biochem Biophys Res Commun
; 207(3): 933-42, 1995 Feb 27.
Article
en En
| MEDLINE
| ID: mdl-7532408
ABSTRACT
We have characterized the 5' region of the CALLA/CD10 gene which has been shown to be identical to the membrane-associated enzyme neutral endopeptidase 24.11 (NEP). There is no CAAT or TATA box in the 5' flanking region, upstream of exon 1, but a GC rich region with several Sp1 binding sites. We have detected several putative initiation transcription sites by primer extension and by nuclease S1 analysis. Moreover by reverse transcriptase-polymerase chain reaction, we demonstrated the existence of a new exon exon 1bis. This exon can be alternatively spliced as has already been described for exon 1 and exon 2.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neprilisina
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia