Human muscle macrophages express beta-amyloid precursor and prion proteins and their mRNAs.
Neuroreport
; 6(7): 1045-9, 1995 May 09.
Article
en En
| MEDLINE
| ID: mdl-7632892
ABSTRACT
Well-characterized antibodies against beta-amyloid precursor protein (beta APP) and prion protein (PrP), and specific cRNA probes, were used to localize beta APP and PrP and their mRNAs in human muscle macrophages. Macrophages present in muscle biopsies of 51 patients with various neuromuscular disorders showed accumulation of beta APP and PrP, and strongly expressed beta APP and PrP mRNAs. These were present in all muscle macrophages unrelated to their localization within the muscle tissue or diagnosis. Our study provides the first demonstration that human muscle resident macrophages synthesize and accumulate beta APP and PrP. We suggest that those proteins play a role in biology of muscle macrophages, including their participation in inflammatory and immune responses.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Priones
/
ARN Mensajero
/
Precursor de Proteína beta-Amiloide
/
Macrófagos
/
Músculos
Límite:
Adolescent
/
Adult
/
Aged
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Child
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos