The NOD mouse.
Diabetes Res Clin Pract
; 24 Suppl: S307-11, 1994 Oct.
Article
en En
| MEDLINE
| ID: mdl-7859625
ABSTRACT
The NOD mouse was discovered and established as an inbred strain in Japan. It is an excellent animal model for human Type 1 (insulin-dependent) diabetes mellitus in many aspects, including genetics, immunology, virology, and prevention and therapy. The diabetes and/or insulitis is controlled by at least 10 genes and results from the T cell-mediated destruction of beta cells. Retrovirus might also play a role in the pathogenesis. Insulitis and/or diabetes of the mice is easily prevented by a number of agents or manipulations, suggesting that diabetes of the mice develops only when many diabetogenic factors assemble. Some of the intervention trials using the mice are hoped to be applied to human Type 1 diabetes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratones Endogámicos NOD
/
Diabetes Mellitus Tipo 1
/
Modelos Animales de Enfermedad
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Diabetes Res Clin Pract
Asunto de la revista:
ENDOCRINOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón