Effects of intravenous superoxide dismutase and catalase on electroretinogram in the cat postischemic retina.
Ophthalmic Res
; 26(3): 163-8, 1994.
Article
en En
| MEDLINE
| ID: mdl-8090434
ABSTRACT
We examined the effects of the antioxidant enzymes, 10,000 U/kg of superoxide dismutase (SOD) and 50,000 U/kg of catalase (CAT) on cat electroretinograms during the reperfusion after retinal ischemia. The intravenous administrations of SOD and CAT promoted the recovery of the c-wave after 30 min of ischemia but not the b-wave. At 5 min after onset of reperfusion, SOD- and CAT-treated eyes showed 90 and 110% recovery of the c-wave amplitude respectively, against 50% recovery in the untreated eyes. These results suggested that the oxygen-derived free radicals affected the retinal pigment epithelium at the early period of reperfusion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retina
/
Vasos Retinianos
/
Superóxido Dismutasa
/
Catalasa
/
Isquemia
Límite:
Animals
Idioma:
En
Revista:
Ophthalmic Res
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón