Amino acid alcohols: growth inhibition and induction of differentiated features in melanoma cells.
Cancer Lett
; 69(3): 203-8, 1993 May 14.
Article
en En
| MEDLINE
| ID: mdl-8099846
ABSTRACT
The effects of a series of D- and L-amino acid alcohols on the proliferation and phenotypic expression of B16 mouse melanoma cells were evaluated. B16 melanoma cells were incubated for different time intervals in the presence of D- or L-phenylalaninol (PHE), D- or L-alaninol (AL), D- or L-leucinol (LE), L-histidinol (HIS), L-tyrosinol (TYR) and L-methioninol (MET). All agents, including the D or L configuration, induced an anti-proliferative effect, although of considerably different magnitude. D-PHE was the most active growth inhibitor. The growth inhibitory effects were accompanied by phenotypic alterations, which included morphological changes and enhancement in the activities of NADPH cytochrome c reductase and tau-glutamyl transpeptidase. These phenotypic alterations correlated with the growth inhibitory effects of the different agents and seem to reflect a higher differentiated state.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Melanoma Experimental
/
Amino Alcoholes
Límite:
Animals
Idioma:
En
Revista:
Cancer Lett
Año:
1993
Tipo del documento:
Article
País de afiliación:
Israel