Antitussive effect of oxatomide on citric acid-induced cough in conscious guinea pig. Preliminary communication.
Arzneimittelforschung
; 43(5): 550-3, 1993 May.
Article
en En
| MEDLINE
| ID: mdl-8101081
ABSTRACT
Oxatomide (CAS 60607-34-3), a diphenylmethyl-piperazine benzimidazole derivative is a new oral antiallergic drug useful in asthma in preventing allergic attacks. Using the model of citric acid-induced coughing in the unanesthetized, unrestrained guinea pig the antitussive effect of oxatomide was investigated. The animals were treated with logarithmically increasing doses of oxatomide (0.5, 1, 2 mg/kg, suspended in 0.5 ml of polyethylene glycol 200 + 0.5 ml of saline) and with the vehicle alone administered intraperitoneally (1 ml) 45 min before the challenge. Oxatomide reduced the number of coughs during the 3 min of challenge, lengthened the time of onset and reduced the number of coughs after cessation of the challenge significantly and a linear dose-effect regression was observed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antitusígenos
/
Piperazinas
/
Tos
/
Antagonistas de los Receptores Histamínicos H1
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia