Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder.
Am J Psychiatry
; 151(4): 594-6, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8147460
ABSTRACT
Stimulatory (Gs) and inhibitory (G(i)) guanine nucleotide binding protein alpha subunit levels were measured in mononuclear leukocytes from 22 drug-free depressed patients (eight with bipolar disorder, 14 with major depressive disorder) and a comparison group of 17 age- and sex-matched healthy subjects. The levels of Gs alpha and G(i) alpha were significantly higher (160% and 114%, respectively) in the bipolar patients, but not the patients with major depressive disorder, than in the healthy subjects. These data add to the evidence for abnormalities in G protein levels and function in the pathophysiology of bipolar disorder.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
/
Leucocitos Mononucleares
/
Proteínas de Unión al GTP
/
Trastorno Depresivo
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Psychiatry
Año:
1994
Tipo del documento:
Article
País de afiliación:
Canadá