Effect of the (alpha 2-->8)-linked polysialic acid capsule on adherence of Neisseria meningitidis to human mucosal cells.
J Infect Dis
; 167(2): 475-9, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-8380612
ABSTRACT
The effect of (alpha 2-->8)-linked polysialic acid on the adherence of Neisseria meningitidis to human mucosal cells was examined using a serogroup B-encapsulated strain and a capsule-defective (Cap-) mutant of this strain. The Cap- mutant contains a single truncated insert of Tn916 in a 3.8-kb HaeIII chromosomal fragment. The Tn916 insert was shown to be responsible for the phenotype by linkage studies and by demonstration that loss of the insert restored encapsulation. The Cap- mutant consistently adhered to human buccal epithelial cell in greater numbers than the encapsulated parent, but the increase in adherence was less than twofold. Adherence of the Cap- mutant during infection of human nasopharyngeal organ cultures was 1.3- to 6.5-fold greater than that of the encapsulated parent. However, specificity of adherence of meningococci for nonciliated nasopharyngeal epithelial cells and the ability to be internalized by these cells was not due to the (alpha 2-->8)-linked polysialic acid capsule.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Ácidos Siálicos
/
Adhesión Bacteriana
/
Cápsulas Bacterianas
/
Mucosa Bucal
/
Neisseria meningitidis
Límite:
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
1993
Tipo del documento:
Article