Pemoline effects on children with ADHD: a time-response by dose-response analysis on classroom measures.
J Am Acad Child Adolesc Psychiatry
; 34(11): 1504-13, 1995 Nov.
Article
en En
| MEDLINE
| ID: mdl-8543519
ABSTRACT
OBJECTIVE:
To evaluate the dose-response by time-response characteristics of pemoline (Cylert) on dependent measures of behavior and academic performance in a laboratory classroom.METHOD:
After a 2-week baseline, a double-blind crossover design was used to compare placebo, 18.75 mg, 37.5 mg, 75 mg, and 112.5 mg of pemoline, q.a.m., with each dose administered for 1 week. Medication was given at 900 A.M., and performance was measured beginning immediately and beginning 2, 4, and 6 hours after ingestion. The dependent measures included number of math problems completed correctly, teacher-recorded rates of on-task behavior and noncompliance, and teacher ratings on an Abbreviated Conners Teacher Rating Scale.RESULTS:
There were linear effects of medication, with pemoline doses greater than 18.75 mg having an effect beginning 2 hours after ingestion and lasting through the seventh hour after ingestion.CONCLUSIONS:
Results are contrasted with widespread misbeliefs regarding pemoline's time course and efficacy.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pemolina
/
Trastorno por Déficit de Atención con Hiperactividad
/
Instituciones Académicas
/
Relación Dosis-Respuesta a Droga
/
Estimulantes del Sistema Nervioso Central
Tipo de estudio:
Clinical_trials
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Am Acad Child Adolesc Psychiatry
Asunto de la revista:
PEDIATRIA
/
PSIQUIATRIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos