HIV gp120-specific cell-mediated immune responses in mice after oral immunization with recombinant Salmonella.
J Acquir Immune Defic Syndr Hum Retrovirol
; 10(5): 489-95, 1995 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-8548327
ABSTRACT
Salmonella is of great interest as a potential human immunodeficiency virus vaccine vector because of its ability to elicit potent mucosal and systemic immune responses when administered orally. To determine whether such a vaccine could elicit an immune response in mice, plasmids expressing HIV gp120-LAI were introduced into attenuated S. typhimurium. Three serial doses of 10(10) recombinant organisms were administered orally to BALB/c mice at 2-week intervals. Immunized mice but not control mice demonstrated proliferative T cell responses to gp120-LAI, comparable in magnitude to the proliferative responses to Salmonella antigens. Immunized mice had detectable serum and intestinal Salmonella-specific IgA and serum Salmonella-specific IgG. However, no gp120-specific antibody was detected in either serum or intestinal washes. These results indicate that live recombinant Salmonella-based vaccine constructs can induce HIV-specific cellular immune responses in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
Problema de salud:
2_enfermedades_transmissibles
/
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Salmonella typhimurium
/
Vacunas Sintéticas
/
Proteína gp120 de Envoltorio del VIH
/
Infecciones por VIH
/
VIH-1
/
Inmunización
/
Vacunas contra el SIDA
Límite:
Animals
Idioma:
En
Revista:
J Acquir Immune Defic Syndr Hum Retrovirol
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
/
VIROLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos