Rare association of human herpesvirus 6 DNA with human papillomavirus DNA in cervical smears of women with normal and abnormal cytologies.
J Clin Microbiol
; 34(6): 1589-91, 1996 Jun.
Article
en En
| MEDLINE
| ID: mdl-8735129
ABSTRACT
We investigated by nested PCR the possible association of human herpesvirus 6 (HHV-6) and human papillomavirus (HPV) genomes in the cervixes of 109 women with normal and abnormal cytological smears. HPV DNA was detected in 8.33% of 24 women with normal cytologies and in 41.1% of 85 women with abnormal cytologies; the proportion of HPV DNA was directly related to the severity of the lesions. HHV-6 DNA was found in only one patient, who had a cytological pattern of koilocytosis. The HHV-6 genome was classified by restriction enzyme analysis as variant B. The study indicates that detection of the HHV-6 genome in the cervixes of women with a wide spectrum of gynecological complaints is a rare event and rules out the possible association between HHV-6 and HPV genomes in cervical cancer lesions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
ADN Viral
/
Cuello del Útero
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Herpesvirus Humano 6
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Clin Microbiol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Italia