Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity.
Ann Pharmacother
; 30(7-8): 762-5, 1996.
Article
en En
| MEDLINE
| ID: mdl-8826556
ABSTRACT
OBJECTIVE:
To describe a patient who developed hepatotoxicity, reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction, apparently caused by acute acetaminophen toxicity.SETTING:
University-affiliated hospital. CASESUMMARY:
A 19-year old white women who took an overdose of acetaminophen developed hepatotoxicity and reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction. Symptoms, signs, and laboratory findings regressed with symptomatic therapy during the follow-up period.CONCLUSIONS:
We believe that acute acetaminophen toxicity was responsible for these hematologic abnormalities. This profile of hematologic adverse effects associated with acetaminophen toxicity has not been reported previously.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
/
Trombocitosis
/
Médula Ósea
/
Analgésicos no Narcóticos
/
Agranulocitosis
/
Reacción Leucemoide
/
Acetaminofén
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Ann Pharmacother
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
1996
Tipo del documento:
Article
País de afiliación:
Turquía