Cytogenetic studies on a patient with prepubertal breast cancer: a case report.
Breast Cancer Res Treat
; 39(3): 343-7, 1996.
Article
en En
| MEDLINE
| ID: mdl-8877015
ABSTRACT
Cytogenetic studies were carried in a 10 year old girl with prepubertal breast cancer for assessing inherited genetic susceptibility to chromosome breakage. The girl presented with a tumour in the left breast. Histologically it was diagnosed as secretory carcinoma (SC). Chromosome anomalies observed in phytohemagglutinin (PHA-P) stimulated lymphocytes were del(2)(q33), del(3)(p24), del(7)(q22) and dup(12)(p11p12). The regions involved have been reported in breast tumors. These loci, detected in peripheral blood lymphocytes (PBL), could be the sites susceptible to breakage, its subsequent effect being manifested in the target (breast) tissue.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Aberraciones Cromosómicas
Límite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Breast Cancer Res Treat
Año:
1996
Tipo del documento:
Article
País de afiliación:
India