Inhibition of regain in body weight and fat with addition of 3-carbon compounds to the diet with hyperenergetic refeeding after weight reduction.
Int J Obes Relat Metab Disord
; 20(10): 925-30, 1996 Oct.
Article
en En
| MEDLINE
| ID: mdl-8910097
ABSTRACT
OBJECTIVE:
To investigate the efficacy of the 3-carbon compounds pyruvate and dihydroxyacetone (PD) in inhibiting reaccumulation of body weight and fat with refeeding after weight loss.DESIGN:
Longitudinal, in Clinical Research Center. After weight loss induced by hypoenergetic diet (1.3 MJ/d) for 3 weeks, refeeding with hyperenergetic diet (1.5 x resting energy expenditure) for 3 weeks. Refeeding diet randomized to contain PD or placebo (PL, polyglucose) as approximately 20% of energy intake.SUBJECTS:
17 obese healthy women (n = 8 in PL group, n = 9 in PD group) (age 22-60 y, weight 72.5-139.7 kg). MEASUREMENTS Resting energy expenditure (REE), body composition (by bioelectrical impedance), nitrogen balance, serum proteins, biochemical profile, thyroid hormones, and insulin, before and after refeeding and weight and fat gain.RESULTS:
Refeeding with a hyperenergetic diet, weight gain was significantly less in patients receiving PD compared to placebo (1.8 + 0.2 kg vs 2.9 +/- 0.1 kg, P < 0.01). Body fat regain was also less with feeding of PD (0.8 +/- 0.2 kg vs 1.8 +/- 0.2 kg, P < 0.01). Body protein metabolism, as measured by nitrogen balance, serum protein concentrations and fat free mass, was similar in subjects consuming either PD or PL.CONCLUSIONS:
We conclude that 3-carbon compounds decrease weight gain and reaccumulation of body fat, without decreasing body protein gain, in obese subjects with hyperenergetic refeeding subsequent to weight loss.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Composición Corporal
/
Ingestión de Energía
/
Pérdida de Peso
/
Ácido Pirúvico
/
Dihidroxiacetona
/
Obesidad
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Obes Relat Metab Disord
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos