Prenatal exposure to morphine alters analgesic responses and preference for sweet solutions in adult rats.
Pharmacol Biochem Behav
; 55(4): 629-34, 1996 Dec.
Article
en En
| MEDLINE
| ID: mdl-8981594
ABSTRACT
In the present study, we examined long-term effects of prenatal morphine on pain response and on preference for sweet solutions. Pregnant Fischer 344 rats were given increasing doses of morphine (0.75-12.0 mg/day) in slow-release emulsion, during gestational days 12-18. Control rats were injected with vehicle and were either pair-fed to morphine rats, or ad libitum fed. At birth, all litters were culled to 8-10 pups (half males and half females) and cross-fostered to naive, surrogate dams. Testing began when rats were 10-12 week old. Rats prenatally exposed to morphine exhibited higher analgesia in response to a morphine challenge, and a greater preference for saccharin solution as compared with both control groups. These findings indicate that prenatal morphine induces long-lasting alterations of systems involved in reward processes and in opiate analgesia, perhaps by modulating endogenous opiate systems.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Sacarina
/
Edulcorantes
/
Gusto
/
Analgésicos Opioides
/
Morfina
Aspecto:
Patient_preference
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1996
Tipo del documento:
Article
País de afiliación:
Israel