Ibogaine selectively inhibits nicotinic receptor-mediated catecholamine release.
Eur J Pharmacol
; 317(2-3): R1-2, 1996 Dec 19.
Article
en En
| MEDLINE
| ID: mdl-8997631
ABSTRACT
The effects of ibogaine, a putative anti-addictive drug, on stimulated catecholamine release were examined in cultured chromaffin cells to clarify its mechanism(s) of action. Low concentrations of ibogaine (1-10 microM) had a selective inhibitory action on nicotinic receptor-mediated catecholamine release, while higher concentrations (100 microM) inhibited additional modes of stimulated catecholamine release. These results suggest a selective inhibitory action of ibogaine at the nicotinic acetylcholine receptor, possibly at the receptor ion channel site.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psicotrópicos
/
Catecolaminas
/
Receptores Nicotínicos
/
Antagonistas Nicotínicos
/
Ibogaína
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos