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Alteration of midkine expression associated with chemically-induced differentiation in human neuroblastoma cells.
Koshizawa, S H; Matsumura, T; Kadono, Y; Sawada, T; Kadomatsu, K; Muramatsu, H; Muramatsu, T.
Afiliación
  • Koshizawa SH; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyoku, Japan.
Cancer Lett ; 111(1-2): 117-25, 1997 Jan 01.
Article en En | MEDLINE | ID: mdl-9022136
ABSTRACT
Midkine (MK), a neurotrophic polypeptide of which expression is developmentally regulated in embryogenesis, is expressed in malignant tumor tissues including neuroblastoma (NB). A retinoic acid analogue, E5166, and dibutyryl cyclic AMP (dbcAMP) are known to induce differentiation in NB cells. This study showed that MK mRNA expression increased in association with differentiation by E5166, but not by dbcAMP in SK-N-SH and KP-N-RTBM1 human NB cell lines. We concluded that MK could be an important factor in differentiation of NB cells, and further, that there could be at least two pathways in differentiation of NB cells at molecular mechanism.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Citocinas / Proteínas de Neoplasias / Neuroblastoma Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Lett Año: 1997 Tipo del documento: Article País de afiliación: Japón
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Citocinas / Proteínas de Neoplasias / Neuroblastoma Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Lett Año: 1997 Tipo del documento: Article País de afiliación: Japón
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