Alteration of midkine expression associated with chemically-induced differentiation in human neuroblastoma cells.
Cancer Lett
; 111(1-2): 117-25, 1997 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-9022136
ABSTRACT
Midkine (MK), a neurotrophic polypeptide of which expression is developmentally regulated in embryogenesis, is expressed in malignant tumor tissues including neuroblastoma (NB). A retinoic acid analogue, E5166, and dibutyryl cyclic AMP (dbcAMP) are known to induce differentiation in NB cells. This study showed that MK mRNA expression increased in association with differentiation by E5166, but not by dbcAMP in SK-N-SH and KP-N-RTBM1 human NB cell lines. We concluded that MK could be an important factor in differentiation of NB cells, and further, that there could be at least two pathways in differentiation of NB cells at molecular mechanism.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Citocinas
/
Proteínas de Neoplasias
/
Neuroblastoma
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón