TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients.
J Neuroimmunol
; 72(2): 149-53, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9042107
ABSTRACT
TNF-alpha production in whole blood cultures upon stimulation with LPS was determined in 179 individuals from 61 families in order to characterise the magnitude of inherited differences in TNF-alpha production. The three families characterised by highest TNF production showed 7.1 +/- 0.3 ng TNF/ml upon culture with 10 ng LPS and 10.2 +/- 0.2 ng TNF/ml upon culture with 1000 ng LPS. in contrast to the three families characterised by the lowest TNF production that showed a production of 1.6 +/- 0.1 ng TNF upon culture with 10 ng and 2.5 +/- 0.2 ng/ml upon culture with 1000 ng LPS/ml. This difference could not be attributed to the promoter polymorphisms -308 G to A. -238 G to A or -376 G to A, although the -238 GA donors produced 2.1 +/- 0.9 ng TNF upon culture with 10 ng endotoxin compared to 3.2 +/- 2.2 ng TNF for the -238 GG donors. In line with these results the frequency of the -238 GG genotype was increased in hospitalized MS patients in a nursing home (100% 238GG, n = 57) compared to MS patients in an outpatient's clinic (94% 238GG, n = 98) or Dutch controls (90% 238GG, n = 180). These results suggest that the -238 GG genotype is differently distributed in hospitalized MS patients in a nursing home.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Regiones Promotoras Genéticas
/
Factor de Necrosis Tumoral alfa
/
Esclerosis Múltiple
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
J Neuroimmunol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Países Bajos