Ovine fetal malformations induced by in utero inoculation with Main Drain, San Angelo, and LaCrosse viruses.
Am J Trop Med Hyg
; 56(2): 171-6, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9080876
ABSTRACT
The teratogenic potential of three bunyaviruses, two California serogroup bunyaviruses, LaCrosse virus and San Angelo virus, and a Bunyamwera serogroup member, Main Drain virus, in sheep was studied following in utero inoculation of ewes in early gestation. Although Main Drain virus appeared to be most teratogenic, all three viruses induced a range of lesions including arthrogryposis, hydrocephalus, fetal death, axial skeletal deviations, anasarca, and oligohydramnios. The teratogenic effects of these viruses are identical to those described in ovine infections by Cache Valley and Akabane viruses. Demonstration of a common bunyaviral tropism for fetal tissue infection that results in congenital brain and musculoskeletal malformations provides evidence that human in utero infection by bunyaviruses could result in similar malformations in human infants.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
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Enfermedades de las Ovejas
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Anomalías Múltiples
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Virus Bunyamwera
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Virus de la Encefalitis de California
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Infecciones por Bunyaviridae
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Feto
Límite:
Animals
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Pregnancy
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos