AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain.
Eur J Pharmacol
; 321(1): R1-3, 1997 Feb 19.
Article
en En
| MEDLINE
| ID: mdl-9083796
ABSTRACT
This research was designed to determine the action of the novel aminoalkylindole AM630 (6-iodo-pravadoline) at the cannabinoid receptor by studying its interaction with the cannabinoid receptor agonist WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]-1,4-benzoxazin-y]-(1-naphthalenyl)methanone mesylate) on guanosine-5'-O-(3-[35S]thio) triphosphate ([35S]GTP gamma S) binding in mouse brain. WIN 55,212-2 stimulated [35S]GTP gamma S binding, while AM630 had no effect. AM630 antagonized WIN 55,212-2-2induced [35S]GTP gamma S binding and shifted the WIN 55,212-dose-response curve to the right. These results clearly demonstrate that AM630 exerts cannabinoid receptor antagonist properties in the brain.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Cannabinoides
/
Guanosina 5'-O-(3-Tiotrifosfato)
/
Indoles
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos