Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats.
Neurosci Lett
; 226(3): 163-6, 1997 May 02.
Article
en En
| MEDLINE
| ID: mdl-9175592
ABSTRACT
Post-injury sprouting of hippocampal mossy fibers has been suggested to be a causal mechanism underlying the development of temporal lobe epilepsy. However, this hypothesis rests entirely on indirect correlational evidence. Here we demonstrate that cycloheximide, a protein synthesis inhibitor, blocked pilocarpine- and kainate-induced mossy fiber sprouting in rats, but did not prevent the subsequent development of spontaneous seizures or affect their frequency. These results provide direct evidence against a causal role for mossy fiber sprouting in temporal lobe epileptogenesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pilocarpina
/
Inhibidores de la Síntesis de la Proteína
/
Agonistas Muscarínicos
/
Agonistas de Aminoácidos Excitadores
/
Cicloheximida
/
Epilepsia
/
Ácido Kaínico
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil