[Effect of indomethacin on the intracranial pressure]. / Indomethacins virkning på det intrakranielle tryk.
Ugeskr Laeger
; 159(27): 4261-5, 1997 Jun 30.
Article
en Da
| MEDLINE
| ID: mdl-9229882
ABSTRACT
Twenty patients subjected to craniotomy for supratentorial cerebral tumours were anaesthetized with thiopental, fentanyl, nitrous oxide, and isoflurane. A PaCO2 level averaging 4.8 kPa was achieved. The patients were randomized to intravenous indomethacin 50 mg or placebo administrated after exposure of the dura. A significant decrease in intracranial pressure from 6.5 to 1.5 mmHg (medians) was found after indomethacin administration. This decrease was caused by a significant decrease in cerebral blood flow associated with a significant increase in the arterio-venous oxygen difference. Indomethacin did not affect cerebral oxygen uptake, arteriovenous difference in lactate or the lactate/oxygen index, suggesting that indomethacin did not provoke global cerebral ischaemia. In the indomethacin group, dura was sufficiently relaxed in eight of nine patients, and dura was opened without the occurrence of cerebral swelling. In the placebo group, mannitol supplemented with hypocapnia was applied in five patients. These findings suggest that perioperative treatment with indomethacin is an excellent treatment of intracranial hypertension during normocapnic isoflurane anaesthesia for craniotomy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Neoplasias Encefálicas
/
Presión Intracraneal
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Circulación Cerebrovascular
/
Antiinflamatorios no Esteroideos
/
Indometacina
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
Da
Revista:
Ugeskr Laeger
Año:
1997
Tipo del documento:
Article