A phase II trial of deferoxamine in patients with hormone-refractory metastatic prostate cancer.
Cancer Invest
; 15(4): 311-7, 1997.
Article
en En
| MEDLINE
| ID: mdl-9246151
ABSTRACT
The management of hormone-refractory metastatic prostate cancer remains a therapeutic dilemma. We report the results of a phase II trial with deferoxamine administrated at a dose of 50 mg/kg (maximum dose 5 g) administered intravenously over 8 hr daily, repeated for 5 days at 4-week intervals for 2 courses. Fourteen patients with advanced hormone-refractory prostate cancer were treated and 28 courses were delivered. Essentially no toxicity was observed. Using combined clinical and prostate-specific antigen (PSA) criteria. 13 of 14 patients had disease progression. However, 9 of 14 patients had stable measurable or evaluable disease and progressed solely based on PSA criteria. Deferoxamine in this dose and schedule has no activity in hormone-refractory prostate cancer. Further investigation of the effect of deferoxamine on PSA production/expression is warranted.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Adenocarcinoma
/
Deferoxamina
/
Antineoplásicos
Límite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Invest
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos