Neuronal ceroid-lipofuscinosis in a domestic cat: clinical, morphological and immunohistochemical findings.
J Comp Pathol
; 117(1): 17-24, 1997 Jul.
Article
en En
| MEDLINE
| ID: mdl-9263841
A 9-month-old domestic shorthair cat was humanely killed because of uncoordinated gait, myoclonus, seizures and reduced vision. Histological, immunohistochemical and ultrastructural examination revealed a neuronal storage disease consistent with neuronal ceroid-lipofuscinosis (NCL). Neurons contained Sudan black- and luxol fast blue-positive material which was autofluorescent. Immunohistochemically, the storage material was found to contain subunit c of mitochondrial ATP synthase, a protein recently recognized as the main component of the storage material in NCL. Ultrastructurally, the material consisted of curvilinear and fingerprint bodies, which are indicative of NCL.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Enfermedades de los Gatos
/
Lipofuscinosis Ceroideas Neuronales
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Austria