Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man.
Circulation
; 96(10): 3774-7, 1997 Nov 18.
Article
en En
| MEDLINE
| ID: mdl-9396482
ABSTRACT
BACKGROUND:
While estrogens protect against coronary artery disease in women, it is unclear whether they influence cardiovascular function in men. The present report describes coronary vascular abnormalities and the lipoprotein profile of a male patient with estrogen insensitivity caused by a disruptive mutation in the estrogen-receptor gene. METHODS ANDRESULTS:
Stress thallium scintigraphy, echocardiography, and electron-beam computed tomography (CT) scanning of the coronary arteries and detailed lipoprotein analysis were performed. Electron-beam CT scanning of the coronary arteries showed calcium in the left anterior descending artery. Lipoprotein analysis showed relatively low levels of total (130 mg/dL), LDL (97 mg/dL), and HDL (34 mg/dL) cholesterol; apolipoprotein A-I (91.7 mg/dL); and lipoprotein(a) (4.1 nmol/L), but normal levels of triglycerides (97 mg/dL) and pre-beta-1-HDL cholesterol (61 microg/mL).CONCLUSIONS:
The absence of functional estrogen receptors may be a novel risk factor for coronary artery disease in men.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Estrógenos
/
Enfermedad Coronaria
/
Mutación
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Circulation
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos