[Sequential treatment with granulocyte-colony stimulating factor (GCSF) and human recombinant erythropoietin (rH-EPO) in anemia of a patient with myelodysplastic syndrome and high blood transfusion requirements)]. / Tratamiento secuencial con factor estimulante de colonias de granulocitos (FEC-G) y eritropoyetina recombinante humana (EPO-rHu) en la anemia de un paciente con síndrome mielodisplásico y altos requerimientos transfusionales.
Gac Med Mex
; 133(4): 355-9, 1997.
Article
en Es
| MEDLINE
| ID: mdl-9410796
ABSTRACT
We describe the case of a patient with myelodysplastic syndrome (MDS) classified as Refractory Anemia with our Excess blasts, who suffered from high transfusional requirements and who did not respond to the administrations of B12 vitamin, folates, danazol, low dose cytarabine or recombinant human erythropoietin (rHuEPO). The patient was administered two cytokines granulocyte colony stimulating factor (G-CSF) followed by rHuEPO. The patient remained transfusion free for more than 4 months until his death from causes not related to MDS or the therapy he received. It is the opinion of the authors that the initial G-CSF administration stimulated the early erythroid precursors, making them capable of finishing their maturation when rHuEPO was administered. We believe that this could be a useful therapeutic measure in the treatment of patients with MDS and high transfusional requirements.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anemia Refractaria
/
Factor Estimulante de Colonias de Granulocitos
/
Eritropoyetina
/
Transfusión de Eritrocitos
Límite:
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Gac Med Mex
Año:
1997
Tipo del documento:
Article