Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells.
J Virol
; 72(1): 882-5, 1998 Jan.
Article
en En
| MEDLINE
| ID: mdl-9420305
ABSTRACT
The primary CD8+ T-cell response protected most B-cell-deficient muMT mice against intranasal infection with the HKx31 influenza A virus. Prior exposure did not prevent reinfection upon homologous challenge, and the recall CD8+ T-cell response cleared the virus from the lung within 7 days. Depleting the CD8+ T cells substantially reduced the capacity of these primed mice to deal with the infection, in spite of evidence for established CD4+ T-cell memory. Thus, the control of this relatively mild influenza virus by both primary and secondary CD4+ T-cell responses is relatively inefficient in the absence of B cells and CD8+ T cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Linfocitos B
/
Linfocitos T CD4-Positivos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos