Mendelian susceptibility to mycobacterial infection in man.
Curr Opin Immunol
; 10(4): 413-7, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9722917
ABSTRACT
Selective susceptibility to poorly pathogenic mycobacteria, such as bacille Calmette-Guérin vaccine and environmental non-tuberculous mycobacteria, has long been suspected to be a mendelian disorder but its molecular basis has remained elusive. Recently, recessive mutations in the interferon-gamma-receptor receptor ligand-binding chain, interferon-gamma-receptor signalling chain, IL-12 p40 subunit and IL-12-receptor beta 1 chain genes have been identified in a number of patients with disseminated mycobacterial infection. Although genetically distinct, these conditions are immunologically related and highlight the essential role of interferon-gamma-mediated immunity in the control of mycobacteria in man.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Mycobacterium
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia