Uterine luminal content of insulin-like growth factor (IGF)-I and endometrial expression of mRNA encoding IGF-binding proteins 1 and 2 during the oestrous cycle and early pregnancy in the ewe.
Reprod Fertil Dev
; 10(2): 155-63, 1998.
Article
en En
| MEDLINE
| ID: mdl-9801267
ABSTRACT
Cyclic (n = 30) and pregnant (n = 29) Merino ewes were examined (n = 3 to 5 at most time points) over Days 0-16 and 0-22 after oestrus, respectively. As IGFBP activity was detected in some plasma and ULF samples, all samples were subjected to acid-gel chromatography before assay for IGF-I. After oestrus, the overall means of both groups of ewes showed lower ULF IGF-I content (Days 3 and 12), lower plasma IGF-I concentrations (Days 3-16), higher endometrial expression of mRNA encoding IGFBP-I (Days 12-16) and lower endometrial expression of mRNA encoding IGFBP-2 (Day 8). Between Days 0 and 16 after oestrus, the pregnant ewes had lower plasma IGF-I concentrations and higher endometrial expression of IGFBP-1 mRNA than did the cyclic ewes. The presence of IGF-I in the ULF throughout the oestrous cycle and early pregnancy suggests a role of IGF-I in early pregnancy, influencing both uterine growth and embryonic survival. The concomitant endometrial expression of mRNA encoding IGFBP-1 and IGFBP-2 suggests a role of these binding proteins in the regulation of IGF-I bioavailability in the uterine environment of the ewe.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Útero
/
Estro
/
Preñez
/
Factor I del Crecimiento Similar a la Insulina
/
Ovinos
/
Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina
/
Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina
/
Endometrio
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Reprod Fertil Dev
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Australia