Evidence that [Phe1 psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord.
Br J Pharmacol
; 125(5): 949-51, 1998 Nov.
Article
en En
| MEDLINE
| ID: mdl-9846631
ABSTRACT
[Phe1 psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a pseudopeptide analogue of nociceptin is an antagonist in peripheral assays. Here, using in vivo electrophysiological recordings of dorsal horn neurones, [Phe1 psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 appears to have agonist activity after spinal administration. The noxious evoked activity of the neurones was inhibited by [Phe1 psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2, which was as potent as nociceptin itself.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Médula Espinal
/
Receptores Opioides
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Péptidos Opioides
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Analgésicos
/
Antagonistas de Narcóticos
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Br J Pharmacol
Año:
1998
Tipo del documento:
Article